| Expression pattern: |
UP |
| Associated gene: |
PAK2, Ago2, MMP2, MMP9, Ki67 |
| Associated microRNA: |
miR-433-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, cell cycle progression, migration, invasion, and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0000119 acts as a sponge for miR-433-3p and regulates PAK2 expression through the circ_0000119/miR-433-3p/PAK2 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000119 expression is associated with significantly lower overall survival in CC patients; circ_0000119 might be a promising diagnostic and therapeutic target for CC. |
| Description: |
circ_0000119 is up-regulated in cervical cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circ_0000119 promotes CC cell proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000119 sponges miR-433-3p to regulate PAK2 expression via the circ_0000119/miR-433-3p/PAK2 axis. |
| Confidence score: |
0.8767 |