| Expression pattern: |
DN |
| Associated gene: |
EI24, NF-kappaB |
| Associated microRNA: |
miR-455-3p |
| Biological function: |
Inhibits breast cancer cell viability, migration, invasion, and tumor growth (tumor suppressor). |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-455-3p, thereby increasing EI24 and inhibiting NF-kappaB activity. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); NF-kappaB (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Sanger Sequencing; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
May be regarded as a novel prognostic predictor and a potential therapeutic target for BC. |
| Description: |
hsa_circ_0043278 is down-regulated in breast cancer tissues and cell lines. It suppresses breast cancer progression by acting as a ceRNA sponge for miR-455-3p, thereby increasing EI24 and inhibiting NF-kappaB activity, which reduces proliferation/viability, migration, invasion, and xenograft tumor growth. |
| Confidence score: |
0.7699 |