| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis in osteosarcoma cells |
| Molecular mechanism: |
circ_0008932 directly binds miR-145-5p and downregulates miR-145-5p; miR-145-5p mediates the effects of circ_0008932 on osteosarcoma cell behaviors |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
circ_0008932 expression was associated with metastasis and high circ_0008932 expression was associated with poor overall survival in osteosarcoma |
| Description: |
circ_0008932 is upregulated in osteosarcoma tissues and cell lines and is associated with metastasis and poor overall survival. Functionally, circ_0008932 promotes osteosarcoma cell proliferation, migration and invasion while inhibiting apoptosis, at least partly by directly binding and repressing miR-145-5p. |
| Confidence score: |
0.7078 |