| Expression pattern: |
DN |
| Associated gene: |
RASSF1A, AGO2 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
Suppresses NSCLC cell proliferation and invasion, promotes apoptosis, and inhibits tumour growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-330-3p, thereby relieving repression of RASSF1A and increasing RASSF1A expression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for NSCLC. |
| Description: |
circ_0078767 is down-regulated in NSCLC tissues and cell lines and suppresses malignant phenotypes. It sponges miR-330-3p to increase RASSF1A expression, thereby inhibiting proliferation/invasion, promoting apoptosis, and reducing xenograft tumour growth. |
| Confidence score: |
0.7756 |