| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Acts as a non-invasive diagnostic and dynamic monitoring biomarker for CRC; higher plasma levels are associated with aggressive clinicopathological features (poor differentiation, lymph node metastasis, higher T stage and TNM stage). |
| Molecular mechanism: |
Not investigated in CRC in this study. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma hsa_circ_0006282 distinguishes primary CRC patients from healthy donors/colitis patients (AUC reported) and decreases to normal after surgery, increasing after recurrence; high plasma expression is associated with poor differentiation, lymph node metastasis, and advanced T/TNM stage. |
| Description: |
This study identifies hsa_circ_0006282 as an up-regulated circRNA in CRC tissues, CRC plasma, and CRC cell lines. Plasma hsa_circ_0006282 shows diagnostic value by ROC analysis and dynamically decreases after surgery and increases upon recurrence, supporting its use as a non-invasive biomarker for CRC monitoring. |
| Confidence score: |
0.5963 |