| Expression pattern: |
UP |
| Associated gene: |
CXCL10 |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
Hsa_circ_0000515 acts as an oncogenic circRNA in breast cancer; it promotes cell cycle progression, proliferation, invasion, angiogenesis, inflammatory response, and tumor growth, while its silencing suppresses these malignant phenotypes. |
| Molecular mechanism: |
Hsa_circ_0000515 functions through a ceRNA-like mechanism by binding miR-296-5p, impairing miR-296-5p-mediated repression of CXCL10 and thereby up-regulating CXCL10 expression to promote breast cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); angiogenesis (promotes); inflammation (promotes); cell cycle (promotes); apoptosis (inhibits); immune regulation (promotes) |
| Detected method: |
Q
B
H
M
|
| Validation methods: |
Microarray; ISH (In Situ Hybridization); RT-qPCR; Northern Blot; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; EdU Staining; Transwell Assay; Cell Cycle Assay; Tube Formation Assay; ELISA; Western Blot; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study |
| Clinical significance: |
Hsa_circ_0000515 was up-regulated in breast cancer tissues and associated with poor prognosis; patients with lower hsa_circ_0000515 expression exhibited longer overall survival. |
| Description: |
Hsa_circ_0000515 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poor prognosis. Mechanistically, cytoplasmic hsa_circ_0000515 binds miR-296-5p and relieves miR-296-5p-mediated repression of CXCL10, promoting breast cancer cell proliferation, invasion, angiogenesis, inflammation, cell-cycle progression, and xenograft tumor growth. |
| Confidence score: |
0.8537 |