| Expression pattern: |
DN |
| Associated gene: |
FOXF2 |
| Associated microRNA: |
miR-454-3p |
| Biological function: |
Inhibits proliferation, migration and invasion and promotes apoptosis of OSCC cells; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a molecular sponge of miR-454-3p to positively regulate FOXF2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model |
| Clinical significance: |
might be a novel biomarker for targeted OSCC therapy |
| Description: |
circGDI2 is down-regulated in OSCC and suppresses malignant phenotypes (proliferation, migration, invasion) while promoting apoptosis. Mechanistically, it sponges miR-454-3p to relieve repression of FOXF2, forming a circGDI2/miR-454-3p/FOXF2 axis that inhibits tumor growth in vivo. |
| Confidence score: |
0.7416 |