| Expression pattern: |
DN |
| Associated gene: |
SOCS5 |
| Associated microRNA: |
miR-587 |
| Biological function: |
Circ_0031027 overexpression inhibits cervical cancer cell proliferation, migration, invasion and tumor growth. |
| Molecular mechanism: |
Circ_0031027 acts through the miR-587/SOCS5 axis, targeting miR-587 and increasing SOCS5 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_0031027 was reduced in cervical cancer tissues, suggesting potential relevance to targeted therapies for cervical cancer. |
| Description: |
Circ_0031027 is downregulated in cervical cancer tissues and cell lines. Its overexpression suppresses cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth, at least partly through the miR-587/SOCS5 regulatory axis. |
| Confidence score: |
0.8001 |