circRNA basic information
circBase ID: hsa_circ_0002980
Name: hsa_circ_AGK
Synonym: hsa_circRNA_104515
Host Gene: AGK
Genomic location(hg19): chr7:141336759-141349133:+
Genomic location(hg38): chr7:141636959-141649333:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AR, MYCN, IGF1, CD34
Associated microRNA: hsa-miR-1303, hsa-miR-142-5p, hsa-miR-877-5p
Biological function: may function as ceRNA
Molecular mechanism: ceRNA mechanism (miRNA sponge) regulating downstream genes (e.g., AR, MYCN, IGF1, CD34)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Sanger Sequencing; Microarray; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circRNA_104515 (hsa_circ_0002980, AGK) is down-regulated in HCC (microarray) and shows a down-regulated tendency by RT-qPCR. Bioinformatic analysis suggests it may act as a ceRNA sponging miR-1303/miR-142-5p/miR-877-5p to regulate hub genes such as AR, MYCN, IGF1 and CD34.
Confidence score:

0.5135
Other information
Title:

A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.

Journal: Journal of translational medicine
Published: 2018
PubMed ID: 30092792
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE94508; GSE97332
Code availability: -