circRNA basic information
circBase ID: hsa_circ_0001667
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:810107-814799:+
Genomic location(hg38): chr7:770470-775162:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent non-malignant tissues
Cell lines:

MDA-MB-468; MCF-7; T47D; BT459; MDA-MB-435; MCF-10A; BT549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TAZ, YAP, SAV1
Associated microRNA: miR-125a-5p
Biological function: Promotes breast cancer cell proliferation, survival and metastasis (migration/invasion).
Molecular mechanism: Acts as a miRNA sponge for miR-125a-5p to derepress TAZ and activate Hippo signaling in breast cancer cells.
Biological pathway or process:

Hippo/YAP (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Microarray
Clinical significance:

High circ_0001667 level is negatively related to patients’ life time and is a potential prognostic marker.
Description:

circ_0001667 is up-regulated in breast cancer tissues and cell lines and its high expression is associated with poorer survival. Functionally, circ_0001667 promotes proliferation/survival and metastasis by sponging miR-125a-5p to increase TAZ (and related Hippo pathway components) activity.
Confidence score:

0.7325
Other information
Title:

Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ.

Journal: Cell & bioscience
Published: 2019
PubMed ID: 31893023
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -