| Expression pattern: |
UP |
| Associated gene: |
FNDC3B, PI3K/mTOR signaling pathway |
| Associated microRNA: |
miR-1225-5p |
| Biological function: |
hsa_circ_0001627 promotes cervical cancer cell proliferation, colony formation, migration, invasion, tumor growth and metastatic activity; knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0001627 functions as a ceRNA/miRNA sponge for miR-1225-5p, thereby upregulating FNDC3B and activating the PI3K/mTOR signaling pathway. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
High hsa_circ_0001627 expression is associated with poor overall survival and correlates with FIGO stage, lymphatic metastasis and HPV infection; it may serve as a prognostic predictor, diagnostic marker and therapeutic target for cervical cancer. |
| Description: |
hsa_circ_0001627 is up-regulated in cervical cancer tissues and cell lines, and high expression predicts poor overall survival. Functionally, it promotes CC cell proliferation, migration, invasion, tumor growth and metastatic activity. Mechanistically, hsa_circ_0001627 sponges miR-1225-5p to increase FNDC3B expression and activate the PI3K/mTOR pathway, suggesting potential diagnostic, prognostic and therapeutic relevance. |
| Confidence score: |
0.798 |