circRNA basic information
circBase ID: hsa_circ_0005556
Name: hsa_circ_NBAS
Synonym: circ_0005556
Host Gene: NBAS
Genomic location(hg19): chr2:15693549-15698758:-
Genomic location(hg38): chr2:15553425-15558634:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; para-carcinoma tissues; tumor tissues
Cell lines:

HGC-27; MKN-28; MGC-803; GES-1; HEK-293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MMP19
Associated microRNA: hsa-miR-4270
Biological function: promotes proliferation, migration and invasion; promotes tumor growth in vivo; promotes EMT
Molecular mechanism: ceRNA mechanism: hsa_circ_0005556 sponges miR-4270 to upregulate MMP19
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

hsa_circ_0005556 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-4270, thereby increasing MMP19 expression and contributing to EMT-related changes.
Confidence score:

0.6544
Other information
Title:

Circular RNA hsa_circ_0005556 Accelerates Gastric Cancer Progression by Sponging miR-4270 to Increase MMP19 Expression.

Journal: Journal of gastric cancer
Published: 2020
PubMed ID: 33024586
Study type:

combined biological and clinical study
Data availability: -
Code availability: -