| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1238, miR-1299 |
| Biological function: |
Promotes CCA cell proliferation and colony formation, enhances migration and invasion/metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) by directly binding miR-1238 and miR-1299; rescue assays indicate oncogenic effects are partly dependent on miR-1238/miR-1299 inhibition. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation |
| Clinical significance: |
circ_0005230 expression is related to larger tumor size, positive lymph node invasion, and advanced TNM stages in CCA patients. |
| Description: |
circ_0005230 is up-regulated in cholangiocarcinoma tissues and cell lines and is associated with more aggressive clinicopathologic features. Functionally, it promotes proliferation, migration/invasion and in vivo tumor growth/metastasis while inhibiting apoptosis, at least partly by sponging miR-1238 and miR-1299. |
| Confidence score: |
0.713 |