| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0001789 is down-regulated in GC tissues and plasma samples, is associated with aggressive clinicopathological features, and may serve as a diagnostic biomarker for gastric carcinoma. |
| Molecular mechanism: |
- |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Down-regulated hsa_circ_0001789 was associated with tumor invasion, differentiation, lymphatic metastasis, TNM stage, and distant metastasis; ROC analysis indicated diagnostic value for GC with AUC 0.82. |
| Description: |
This study identified hsa_circ_0001789 as a human circRNA derived from RAB11FIP1 and found it significantly down-regulated in gastric cancer tissues and plasma. Its reduced expression was associated with more aggressive clinicopathological characteristics, and ROC analysis supported its potential as a diagnostic biomarker for GC. |
| Confidence score: |
0.5047 |