circRNA basic information
circBase ID: -
Name: hsa_circ_RIG-I
Synonym: circRIG-I
Host Gene: -
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circRIG-I interacts with DDX3X, which in turn stimulates MAVS/TRAF5/TBK1 signaling cascade, eventually activating IRF3-mediated type I IFN transcription and aggravating inflammatory damage.
Other information
Title:

Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.

Journal: Nat Commun
Published: 2022/11/20
PubMed ID: 36402769