circRNA basic information
circBase ID: hsa_circ_0029696
Name: hsa_circ_SKA3
Synonym: circ‐SKA3
Host Gene: SKA3
Genomic location(hg19): chr13:21735928-21746820:-
Genomic location(hg38): chr13:21161789-21172681:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007959
MONDO name: medulloblastoma
Disease details: medulloblastoma
Disease DO ID:
 0050902, 0060104
Disease MeSH ID:
 D008527
Disease NCIt ID:
 C3222
Disease ICD11 ID:
 290815825
Disease OMIM ID:
 155255
Species: Human
Species details: Homo sapiens
Tissue specimen:

medulloblastoma tissues; normal cerebellum tissues
Cell lines:

DAOY
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SKA3
Associated microRNA: -
Biological function: Promotes proliferation, migration and invasion of medulloblastoma cells.
Molecular mechanism: Regulates proliferation/migration/invasion by controlling the expression of its host gene SKA3.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Transfection; CCK8; Transwell Assay; Clinical Sample Validation
Clinical significance:

Might be considered as novel and potential biomarkers for the diagnosis and new targets for the intervention of MB.
Description:

circ‐SKA3 is upregulated in medulloblastoma tissues and functions as an oncogenic circRNA in DAOY cells. Its knockdown suppresses proliferation, migration and invasion, and these effects are rescued by SKA3 overexpression, supporting a host-gene-dependent mechanism.
Confidence score:

0.6676
Other information
Title:

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.

Journal: Cancer medicine
Published: 2018
PubMed ID: 30402980
Study type:

combined biological and clinical study
Data availability: -
Code availability: -