| Expression pattern: |
UP |
| Associated gene: |
MACC1 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
circ_0101802 functions as a tumor promoter in colorectal cancer by promoting CRC cell proliferation, migration, invasion, EMT process and tumorigenesis in vivo. |
| Molecular mechanism: |
circ_0101802 acts as a ceRNA sponge for miR-1236-3p, thereby positively regulating MACC1 expression and facilitating CRC proliferation, migration and invasion. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Western Blot; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0101802 expression was related to Enneking stage, differentiation degree, distant metastasis and poor overall survival in CRC patients, suggesting potential prognostic significance. |
| Description: |
circ_0101802 is up-regulated in colorectal cancer tissues and cells, and high expression is associated with poor overall survival and adverse clinicopathological features. Functionally, circ_0101802 promotes CRC proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it sponges miR-1236-3p to positively regulate MACC1 expression through a ceRNA axis. |
| Confidence score: |
0.7859 |