circRNA basic information
circBase ID: hsa_circ_0001721
Name: hsa_circ_CDK14
Synonym: circ_0001721
Host Gene: CDK14
Genomic location(hg19): chr7:90355880-90356126:+
Genomic location(hg38): chr7:90726566-90726812:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
3347
Disease MeSH ID:
D012516
Disease NCIt ID:
C9145
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissue samples; matched non-tumor tissue specimens; paired non-cancerous tissue samples

Cell lines:

hFOB1.19; HOS; Saos2; MG63; U2OS

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-569, miR-599
Biological function: circ_0001721 facilitates osteosarcoma cell progression by promoting proliferation, clone formation, migration, invasion and xenograft tumor growth, while inhibiting apoptosis.
Molecular mechanism: circ_0001721 acts as a miRNA sponge for miR-569 and miR-599; its oncogenic functions are partly dependent on repression/regulation of miR-569 and miR-599.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other); other pathway/process (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Survival Analysis; Cohort Study; Bioinformatics Analysis

Clinical significance:

circ_0001721 overexpression is associated with larger tumor size, advanced WHO grade, and dismal 5-year prognosis; enhanced expression may act as an independent prognostic predictor for OS patients.

Description:

circ_0001721 is up-regulated in osteosarcoma tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes OS cell proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ_0001721 acts partly by sponging miR-569 and miR-599.

Confidence score:

0.7524

Other information
Title:

Upregulation of circular RNA circ_0001721 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-569 and miR-599.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2019
PubMed ID: 30396080
Study type:

combined biological and clinical study

Data availability: -
Code availability: -