| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-569, miR-599 |
| Biological function: |
circ_0001721 facilitates osteosarcoma cell progression by promoting proliferation, clone formation, migration, invasion and xenograft tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0001721 acts as a miRNA sponge for miR-569 and miR-599; its oncogenic functions are partly dependent on repression/regulation of miR-569 and miR-599. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
circ_0001721 overexpression is associated with larger tumor size, advanced WHO grade, and dismal 5-year prognosis; enhanced expression may act as an independent prognostic predictor for OS patients. |
| Description: |
circ_0001721 is up-regulated in osteosarcoma tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes OS cell proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ_0001721 acts partly by sponging miR-569 and miR-599. |
| Confidence score: |
0.7524 |