circRNA basic information
circBase ID: hsa_circ_0001550
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:167915606-167921655:+
Genomic location(hg38): chr5:168488601-168494650:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BEAS-2B; A549; PC9
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOP58
Associated microRNA: -
Biological function: Promotes NSCLC cell proliferation, migration, invasion, and stemness; hsa_circ_0001550 silencing suppresses these malignant phenotypes and reduces stemness marker expression.
Molecular mechanism: NOP58 binds to hsa_circ_0001550 and stabilizes its expression, thereby facilitating NSCLC cell proliferation, migration, invasion, and stemness.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); stemness (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

Actinomycin D / DRB Stability Assay; RT-qPCR; Luciferase Reporter Assay; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for NSCLC therapy; no clinical cohort validation was performed.
Description:

hsa_circ_0001550 is up-regulated in NSCLC cell lines A549 and PC9. Its knockdown inhibits proliferation, migration, invasion, and stemness, while the RBP NOP58 binds to and stabilizes hsa_circ_0001550 to promote these malignant NSCLC cell phenotypes.
Confidence score:

0.6435
Other information
Title:

Overexpression of NOP58 Facilitates Proliferation, Migration, Invasion, and Stemness of Non-small Cell Lung Cancer by Stabilizing hsa_circ_0001550.

Journal: Anti-cancer agents in medicinal chemistry
Published: 2024
PubMed ID: 38994624
Study type:

biological research
Data availability: The analyzed data sets generated during the study are available from the corresponding author upon reasonable request.
Code availability: -