| Expression pattern: |
UP |
| Associated gene: |
ALG3, Ago2 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
CircPTK2 promotes AML cell viability, proliferation, cell cycle process and glycolysis, and inhibits apoptosis; circPTK2 knockdown suppresses malignant biological behaviors of AML cells. |
| Molecular mechanism: |
CircPTK2 acts as a ceRNA/sponge for miR-582-3p, thereby positively regulating ALG3 expression in AML cells. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
CircPTK2 is upregulated in AML peripheral blood samples and might provide a potential target for AML therapy. |
| Description: |
CircPTK2 is upregulated in AML peripheral blood samples and AML cell lines. Functionally, circPTK2 promotes AML cell viability, proliferation, cell cycle progression and glycolysis while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-582-3p to positively regulate ALG3 expression, forming a circPTK2/miR-582-3p/ALG3 axis that contributes to AML malignant behaviors. |
| Confidence score: |
0.7045 |