circRNA basic information
circBase ID: hsa_circ_0000069
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:47745912-47748131:-
Genomic location(hg38): chr1:47280240-47282459:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent noncancerous tissues
Cell lines:

HT-29; LoVo; HCT-116; SW480; HCO
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes CRC cell proliferation, migration and invasion; knockdown induces G0/G1 cell-cycle arrest.
Molecular mechanism: -
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay
Clinical significance:

High expression of hsa_circ_0000069 in CRC tissues and correlated with patients’ age and TNM stage; proposed as a promising target in diagnosis and therapy.
Description:

hsa_circ_0000069 is upregulated in colorectal cancer tissues/cell lines. Its knockdown suppresses CRC cell proliferation, migration and invasion, and induces G0/G1 cell-cycle arrest in vitro, suggesting an oncogenic role and potential diagnostic/therapeutic relevance.
Confidence score:

0.5751
Other information
Title:

Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer.

Journal: OncoTargets and therapy
Published: 2016
PubMed ID: 28003761
Study type:

combined biological and clinical study
Data availability: -
Code availability: -