| Expression pattern: |
DN |
| Associated gene: |
WWOX |
| Associated microRNA: |
miR-92 |
| Biological function: |
inhibits proliferation |
| Molecular mechanism: |
circMTO1 acts as a miRNA sponge for miR-92 to upregulate WWOX expression, thereby inhibiting glioblastoma cell proliferation. |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Lower circMTO1 level was significantly associated with shorter overall survival among patients with glioblastoma. |
| Description: |
circMTO1 is down-regulated in glioblastoma and its low expression is associated with shorter overall survival. Functionally, circMTO1 suppresses glioblastoma cell proliferation by sponging miR-92 and thereby upregulating the tumor suppressor WWOX. |
| Confidence score: |
0.7078 |