| Expression pattern: |
DN |
| Associated gene: |
CREBRF |
| Associated microRNA: |
hsa-miR-329-5p |
| Biological function: |
suppresses AML cell proliferation and promotes apoptosis; inhibits AML tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism; miRNA sponge targeting hsa-miR-329-5p and regulating CREBRF |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); drug resistance (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Luciferase Reporter Assay; Transfection; Western Blot; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Microarray |
| Clinical significance: |
may be a novel potential biomarker for the treatment of AML; may serve as a biomarker for the diagnosis and prognosis in AML |
| Description: |
hsa_circ_0001947 is downregulated in AML and acts as a tumor suppressor. It inhibits AML cell proliferation and promotes apoptosis by sponging hsa-miR-329-5p and relieving repression of CREBRF, and it also shows diagnostic/prognostic potential in patient samples. |
| Confidence score: |
0.8162 |