| Expression pattern: |
UP |
| Associated gene: |
NCAPG, WNT5A, POLA1 |
| Associated microRNA: |
hsa-miR-1306-5p, hsa-miR-326, hsa-miR-1296-5p |
| Biological function: |
Associated with CRC immunoregulatory ceRNA network (functional role not experimentally validated). |
| Molecular mechanism: |
Predicted ceRNA interactions via miRNA sponging affecting hub genes NCAPG, WNT5A, POLA1. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Potential diagnostic and therapeutic paradigm for CRC (no circRNA-specific clinical endpoint reported). |
| Description: |
hsa_circ_0000517 is a co-upregulated RPPH1-derived circRNA in CRC identified from microarray data and detected by qRT-PCR in CRC cell lines. It is included in the predicted ceRNA subnetwork, potentially sponging hsa-miR-1306-5p, hsa-miR-326, and hsa-miR-1296-5p to regulate NCAPG, WNT5A, and POLA1. |
| Confidence score: |
0.4032 |