| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-133b |
| Biological function: |
Contributes to cisplatin resistance of cervical cancer cells; promotes proliferation and inhibits apoptosis in DDP-resistant cervical cancer cells. |
| Molecular mechanism: |
circ_0005273 acts as a competing endogenous RNA that directly sponges miR-133b to modulate miR-133b expression and facilitate DDP resistance. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
circ_0005273 level was associated with DDP status, FIGO stage and overall survival; high circ_0005273 expression was associated with significantly shorter OS rates. |
| Description: |
circ_0005273 is upregulated in cisplatin-resistant cervical cancer tissues and DDP-resistant HeLa/DDP and SiHa/DDP cells. It promotes cisplatin resistance by sponging miR-133b, supporting cell proliferation and suppressing apoptosis; high circ_0005273 expression is associated with FIGO stage, DDP status and poorer overall survival. |
| Confidence score: |
0.8078 |