circRNA basic information
circBase ID: hsa_circ_0064288
Name: hsa_circ_ATG7
Synonym: circRNA ATG7 / circ_0064288
Host Gene: ATG7
Genomic location(hg19): chr3:11348416-11350535:+
Genomic location(hg38): chr3:11306942-11309061:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic nephropathy / DN
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

renal tissue; rat kidney tissue
Cell lines:

RAW264.7; HEK293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: SOCS1, STAT3
Associated microRNA: miR-4500
Biological function: Alleviates renal damage in diabetes nephropathy and promotes macrophage phenotype switching from M1 to M2 (inhibits M1 polarization and inflammation).
Molecular mechanism: Acts as a ceRNA binding miR-4500 to regulate SOCS1/STAT3 signaling, thereby promoting macrophage M2 polarization and reducing inflammatory factors in DN.
Biological pathway or process:

JAK/STAT (inhibits); macrophage polarization (inhibits); inflammation (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

In a streptozotocin-induced DN rat model, exosomal circRNA ATG7 derived from urinary stem cells is down-regulated, and restoring/overexpressing it alleviates renal injury. Mechanistically, circRNA ATG7 targets miR-4500 to modulate the SOCS1/STAT3 signaling pathway, suppressing M1 polarization and promoting M2 macrophage polarization, thereby reducing inflammation in DN.
Confidence score:

0.528
Other information
Title:

Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy.

Journal: International urology and nephrology
Published: 2024
PubMed ID: 37815664
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Code availability: -