| Expression pattern: |
DN |
| Associated gene: |
CRCT1, KLK10 |
| Associated microRNA: |
hsa-miR-125a-5p, hsa-miR-377-3p, hsa-miR-181a-5p, hsa-miR-221-3p, hsa-miR-326, hsa-miR-485-3p, hsa-miR-193a-5p |
| Biological function: |
Overexpression of hsa_circ_0026377 inhibited cervical cancer cell proliferation, migration and invasion. |
| Molecular mechanism: |
predicted ceRNA mechanism within a circRNA-miRNA-mRNA regulatory network |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Sanger Sequencing; RNase R Treatment; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
may provide foundation for diagnosis and treatment of CCa |
| Description: |
hsa_circ_0026377, generated from exons 2-9 of KRT81, was down-regulated in cervical cancer and validated by RT-qPCR. Functional gain-of-function assays showed that hsa_circ_0026377 suppresses HeLa and SiHa cell proliferation, migration and invasion. Bioinformatics analyses placed hsa_circ_0026377 in a predicted circRNA-miRNA-mRNA ceRNA network, suggesting it may regulate cervical cancer progression through miRNA-mediated target gene pathways. |
| Confidence score: |
0.7399 |