circRNA basic information
circBase ID: hsa_circ_0072309
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent normal tissues; non-tumor tissues; lung tissues
Cell lines:

HBE; CALU3; H125; A549; H1299
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-580-3p
Biological function: inhibits NSCLC cell proliferation, migration and invasion
Molecular mechanism: acts as a miRNA sponge by directly binding miR-580-3p
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis
Clinical significance:

provided a novel diagnostic biomarker and potential therapy for NSCLC
Description:

hsa_circ_0072309 is down-regulated in NSCLC tissues and cell lines. Its overexpression suppresses NSCLC cell proliferation, migration and invasion by acting as a cytoplasmic miRNA sponge that directly binds miR-580-3p, and it is proposed as a diagnostic biomarker/therapeutic target for NSCLC.
Confidence score:

0.7372
Other information
Title:

Circular RNA hsa_circ_0072309 inhibits non-small cell lung cancer progression by sponging miR-580-3p.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32293004
Study type:

combined biological and clinical study
Data availability: GSE112214; TCGA
Code availability: -