circRNA basic information
circBase ID: hsa_circ_0060937
Name: hsa_circ_CYP24A1
Synonym: -
Host Gene: CYP24A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

boneless metastasis NSCLC tissues; bone metastasis NSCLC tissues; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes proliferation; promotes invasion; associated with bone metastasis
Molecular mechanism: -
Biological pathway or process:

proliferation (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Survival Analysis; ROC Analysis
Clinical significance:

Expression of serum has_circ_0060937 in the bone metastasis group from Grade I to Grade III NSCLC were drastically higher than the boneless metastasis group or healthy group; overexpression of has_circ_0060937 NSCLC patients were associated with lower survival rate; suggested has_circ_0060937 could serve as a diagnostic biomarker for NSCLC patients with bone metastasis.
Description:

has_circ_0060937 (derived from CYP24A1) is up-regulated in NSCLC tissues and is highest in NSCLC with bone metastasis, including elevated serum levels across bone-metastasis grades. Functionally, its knockdown suppresses proliferation and invasion in NSCLC bone-metastasis cells, and high expression is associated with poorer survival, supporting its potential as a biomarker for NSCLC bone metastasis.
Confidence score:

0.6949
Other information
Title:

Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC.

Journal: International journal of general medicine
Published: 2020
PubMed ID: 33209054
Study type:

combined biological and clinical study
Data availability: GSE112214
Code availability: -