circRNA basic information
circBase ID: hsa_circ_0060551
Name: -
Synonym: circ_0060551
Host Gene: -
Genomic location(hg19): chr20:44444179-44444552:+
Genomic location(hg38): chr20:45815540-45815913:+
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

H8; HeLa; CaSki; C33A; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TPD52, ELAVL1, AGO2
Associated microRNA: miR-520a-5p
Biological function: Promotes migration and invasion of cervical cancer cells; aggravates malignant cell behaviors via regulating TPD52.
Molecular mechanism: circ_0060551 up-regulates TPD52 expression through a ceRNA model by targeting miR-520a-5p and stabilizes TPD52 mRNA by recruiting ELAVL1.
Biological pathway or process:

migration (promotes); invasion (promotes); ceRNA regulation (promotes); mRNA stability (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0060551 is up-regulated in cervical cancer cells and promotes cell migration and invasion. Mechanistically, it up-regulates TPD52 by sponging miR-520a-5p in a ceRNA axis and also recruits ELAVL1 to stabilize TPD52 mRNA.
Confidence score:

0.7404
Other information
Title:

Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.

Journal: American journal of reproductive immunology (New York, N.Y. : 1989)
Published: 2022
PubMed ID: 35716110
Study type:

biological research
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -