circRNA basic information
circBase ID: hsa_circ_0044520
Name: hsa_circ_COL1A1
Synonym: Circ_0044520
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal Oral Epithelial Keratinocytes (HOK), Laryngeal squamous cell carcinoma cell line (SNU899, TU177)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: In vitro complement experiments showed that knockdown of circ_0044520 significantly inhibited malignant behavior of LSCC, while co-transfection of miR-338-3p inhibitor partially up-regulated this change.
Molecular mechanism: Circ_0044520 can sponge hsa-miR-338-3p, and ROR2 is the target of hsa-miR-338-3p.
Survival: -
Supported No.:
 3
Description:

Circ_0044520 silencing plays anti-proliferation and pro-apoptosis roles in LSCC cells by regulating the miR-338-3p/ROR2 axis, suggesting that the circ_0044520/miR-338-3p/ROR2 axis may be a potential regulatory mechanism for the treatment of LSCC.
Other information
Title:

Circ_0044520 regulates the progression of laryngeal squamous cell carcinoma via the miR-338-3p/ROR2 axis.

Journal: Histol Histopathol
Published: 2022/1/18
PubMed ID: 35037694