| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
precursor miR-92b |
| Biological function: |
Circ-MYBL2 suppresses gastric cancer cell proliferation and tumor growth, and suppresses the proliferative effect of mature miR-92b. |
| Molecular mechanism: |
Circ-MYBL2 binds and sponges precursor miR-92b in the nucleus, increases precursor miR-92b accumulation, decreases mature miR-92b levels, and thereby suppresses miR-92b maturation. |
| Biological pathway or process: |
proliferation (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Transfection; BrdU; Northern Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircRNA circ-MYBL2 was closely associated with tumor size, but not other clinical factors. |
| Description: |
Circ-MYBL2 is down-regulated in gastric cancer tissues and cell lines. It acts as a tumor-suppressive circRNA by binding precursor miR-92b, suppressing miR-92b maturation, and inhibiting gastric cancer cell proliferation and xenograft tumor growth. |
| Confidence score: |
0.6824 |