| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-624 |
| Biological function: |
Facilitates HCC progression by increasing HCC cell growth, cell cycle progression, and migration. |
| Molecular mechanism: |
circ_0006404 acts as a sponge for miR-624 and suppresses miR-624 expression in HCC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Wound Healing Assay |
| Clinical significance: |
circ_0006404 might act as one new biomarker for HCC. |
| Description: |
circ_0006404 is up-regulated in HCC specimens and HCC cell lines. Functionally, circ_0006404 promotes HCC cell growth, cell cycle progression, and migration, at least partly by sponging and suppressing miR-624. The study suggests circ_0006404 may serve as a potential biomarker for HCC. |
| Confidence score: |
0.6479 |