circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: circ-0067934 / circ_0067934
Host Gene: -
Genomic location(hg19): chr3:170013698-170015181:+
Genomic location(hg38): chr3:170295910-170297393:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent non-cancerous tissues
Cell lines:

A549; H1299; SK-MES-1; PC-9; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes proliferation in NSCLC cells.
Molecular mechanism: not specified
Biological pathway or process:

proliferation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Survival Analysis
Clinical significance:

High circ-0067934 expression is associated with lymph node metastasis, advanced TNM stage, poor OS, and is an independent risk factor for OS in NSCLC.
Description:

circ-0067934 is up-regulated in NSCLC tissues and cell lines. Its high expression correlates with lymph node metastasis, advanced TNM stage, and poor overall survival, and it acts as an independent risk factor for OS. Functionally, circ-0067934 promotes NSCLC cell proliferation since siRNA-mediated knockdown reduces proliferation and colony formation.
Confidence score:

0.6028
Other information
Title:

Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer.

Journal: Oncology letters
Published: 2018
PubMed ID: 30344708
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed in the present study are available from the corresponding author upon reasonable request.
Code availability: -