| Expression pattern: |
UP |
| Associated gene: |
SHP2, PTPN11, MYBL2, STAT1, STAT3, IFIT1, IFIH1, CXCL10, iNOS |
| Associated microRNA: |
miR-199a-5p, miR-133a-3p, miR-133b |
| Biological function: |
negatively regulates IFN-I-induced inflammation; inhibits macrophage-mediated inflammation |
| Molecular mechanism: |
ceRNA sponge mechanism: hsa_circ_0060450 sponges miR-199a-5p to upregulate SHP2, suppressing IFN-I-triggered JAK-STAT1/3 signaling |
| Biological pathway or process: |
JAK/STAT (inhibits); inflammation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0060450 in PBMCs could discriminate normal subjects and T1DM patients |
| Description: |
hsa_circ_0060450 is up-regulated in PBMCs from children with T1DM and is distributed in both nucleus and cytoplasm. It acts as a miR-199a-5p sponge to relieve repression of SHP2 (PTPN11), thereby suppressing IFN-I-triggered JAK-STAT1/3 activation and reducing macrophage inflammatory responses; it also shows diagnostic potential via ROC analysis in PBMCs. |
| Confidence score: |
0.8261 |