| Expression pattern: |
UP |
| Associated gene: |
ZEB1, ANKRD17 promoter, E-cadherin, N-cadherin, vimentin |
| Associated microRNA: |
- |
| Biological function: |
CircANKRD17 promotes proliferation, invasion, migration, and EMT, and inhibits apoptosis in epithelial ovarian cancer cells. |
| Molecular mechanism: |
The transcription factor ZEB1 binds the ANKRD17 promoter and promotes CircANKRD17 transcription, thereby regulating EOC cell proliferation, invasion, migration, EMT, and apoptosis. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); EMT (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; ChIP / ChIP-seq; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
CircANKRD17 is significantly upregulated in EOC tissues and may provide a potential target or innovative solution for the treatment and diagnosis of EOC. |
| Description: |
CircANKRD17 is upregulated in epithelial ovarian cancer tissues and cell lines. ZEB1 transcriptionally promotes CircANKRD17 expression by binding the ANKRD17 promoter, and CircANKRD17 mediates ZEB1-driven EOC progression by promoting proliferation, invasion, migration, and EMT while inhibiting apoptosis. |
| Confidence score: |
0.7283 |