| Expression pattern: |
DN |
| Associated gene: |
KLF5 |
| Associated microRNA: |
miR-1183 |
| Biological function: |
CircCDK14 overexpression promoted proliferation, inhibited apoptosis, and reduced extracellular matrix degradation in IL-1b-treated chondrocytes; exosomal circCDK14 showed diagnostic value for OA. |
| Molecular mechanism: |
CircCDK14 functions as a ceRNA by sponging miR-1183, thereby upregulating KLF5 expression and ameliorating IL-1b-induced chondrocyte injury. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circCDK14 had high diagnostic value in distinguishing OA patients from healthy controls. |
| Description: |
CircCDK14 is down-regulated in OA cartilage tissues, IL-1b-treated chondrocytes, and serum exosomes from OA patients. Its overexpression protects chondrocytes from IL-1b-induced injury by promoting proliferation, inhibiting apoptosis, and reducing ECM degradation through the miR-1183/KLF5 axis. Serum exosomal circCDK14 also has potential diagnostic value for OA. |
| Confidence score: |
0.8562 |