| Expression pattern: |
DN |
| Associated gene: |
DUSP1 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
CircHIPK3 overexpression alleviated OGD-induced inflammatory response and neuronal apoptosis, promoted proliferation, and reduced caspase-3 activity and BAX expression while increasing BCL2 expression in AGE1.HN cells. |
| Molecular mechanism: |
CircHIPK3 functions as a miR-382-5p sponge and regulates DUSP1 expression through the miR-382-5p/DUSP1 axis. |
| Biological pathway or process: |
inflammation (inhibits); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; ELISA; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
CircHIPK3 might be a promising therapeutic target for SCI. |
| Description: |
CircHIPK3 was down-regulated in OGD-induced AGE1.HN spinal cord injury cell models. Its overexpression alleviated inflammatory response and neuronal apoptosis and promoted cell proliferation by sponging miR-382-5p and regulating DUSP1 expression, suggesting circHIPK3 as a potential therapeutic target for SCI. |
| Confidence score: |
0.7204 |