| Expression pattern: |
UP |
| Associated gene: |
HEG1 |
| Associated microRNA: |
miR-1283 |
| Biological function: |
Promotes HCC cell viability, proliferation, migration, invasion, angiogenesis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0005397 acts as a miR-1283 sponge to regulate HEG1 expression through the circ_0005397/miR-1283/HEG1 axis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0005397 expression is higher in stage III than stage I-II HCC and is enhanced in HCC patients with lymph node metastasis; it is suggested as a potential therapeutic target for HCC. |
| Description: |
circ_0005397 is up-regulated in HCC tissues and cell lines and is associated with advanced stage and lymph node metastasis. It promotes HCC proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-1283 to up-regulate HEG1. |
| Confidence score: |
0.8175 |