circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: Circular RNA ITCH
Host Gene: ITCH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005105
MONDO name: melanoma
Disease details: melanoma
Disease DO ID:
 1909
Disease MeSH ID:
 D008545
Disease NCIt ID:
 C3224
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

melanoma tissues; non-cancer tissues
Cell lines:

A375; M21
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GLUT1
Associated microRNA: -
Biological function: ITCH overexpression suppresses glucose uptake and inhibits melanoma cell proliferation.
Molecular mechanism: ITCH downregulates GLUT1 at mRNA and protein levels, leading to reduced glucose uptake and inhibition of melanoma cell proliferation.
Biological pathway or process:

glycolysis (inhibits); proliferation (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Western Blot
Clinical significance:

ITCH was downregulated in melanoma tissues compared with non-cancer tissues, but its expression was not significantly different among clinical stages.
Description:

Circular RNA ITCH is downregulated in melanoma tissues. In melanoma cells, ITCH overexpression downregulates GLUT1, suppresses glucose uptake, and inhibits cell proliferation, supporting a tumor-suppressive role.
Confidence score:

0.5214
Other information
Title:

Circular RNA ITCH downregulates GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation.

Journal: The Journal of dermatological treatment
Published: 2021
PubMed ID: 31403357
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the study are available from the corresponding author on reasonable request.
Code availability: -