| Expression pattern: |
DN |
| Associated gene: |
HOXB13 |
| Associated microRNA: |
miR-17-5p |
| Biological function: |
Inhibits prostate cancer cell proliferation and colony formation; induces apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-17-5p, thereby upregulating HOXB13 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; BrdU; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circITCH expression level was highly related with preoperative PSA, tumor stage and Gleason score; low circITCH expression was significantly related to poor overall survival. |
| Description: |
CircITCH is down-regulated in prostate cancer tissues and cell lines. Functionally, circITCH overexpression suppresses proliferation/colony formation and promotes apoptosis in vitro and inhibits tumor growth in xenografts, mainly by sponging miR-17-5p to upregulate HOXB13. |
| Confidence score: |
0.7412 |