circRNA basic information
circBase ID: -
Name: hsa_circ_FUT8
Synonym: circFUT8
Host Gene: FUT8
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

FFPE lung cancer tissues; FFPE tissue samples
Cell lines:

PC9; A549; HOP-62; HCC-827; NCI-H1666; NCI-H3122; NCI-H2228; AALE; HBEC30KT
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: YESI
Associated microRNA: hsa-mir-186, hsa-miR-1305, miR-944
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Others
Validation methods:

Bioinformatics Analysis; ROC Analysis
Clinical significance:

Included in an 8-circRNA signature to discriminate NSCLC from nontumor controls; also among 6 circRNAs differentially expressed in early-stage NSCLC vs controls
Description:

circFUT8 is up-regulated in NSCLC FFPE tissues and in lung cancer cell lines based on nCounter profiling, and contributes to an ML-based diagnostic signature distinguishing NSCLC from controls. miRNA binding for circFUT8 was computationally predicted (including hsa-mir-186 and hsa-miR-1305), while a prior study is cited for a miR-944/YESI axis in NSCLC.
Confidence score:

0.2629
Other information
Title:

Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.

Journal: Molecular oncology
Published: 2022
PubMed ID: 35060299
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author (carlospedraz@icloud.com) upon reasonable request.
Code availability: -