| Expression pattern: |
UP |
| Associated gene: |
SZRD1, UBAP2, PCNA, Bcl-2, Bax, Ki67 |
| Associated microRNA: |
miR-638 |
| Biological function: |
Promotes glioma cell proliferation, migration, invasion, angiogenesis and tumorigenicity; inhibits apoptosis. |
| Molecular mechanism: |
ceRNA mechanism: circ_0008344 acts as a sponge for miR-638, thereby regulating SZRD1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0008344 might be a potential pathology, treatment or therapeutic target in glioma. |
| Description: |
Hsa_circ_0008344/circ_0008344 is up-regulated in glioma tissues and glioma cell lines and mainly localized in the cytoplasm. Functionally, it promotes glioma proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-638 to regulate SZRD1 expression, suggesting potential therapeutic relevance in glioma. |
| Confidence score: |
0.8175 |