| Expression pattern: |
DN |
| Associated gene: |
ZBTB1 / zinc finger and BTB domain containing 1 |
| Associated microRNA: |
miR-1229-3p |
| Biological function: |
Circ_0000442 acts as a tumor repressor in breast cancer, repressing proliferation, migration, invasion, glycolysis and tumor growth while promoting apoptosis. |
| Molecular mechanism: |
Circ_0000442 functions through a ceRNA sponge mechanism by binding miR-1229-3p and thereby upregulating ZBTB1 expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); glycolysis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
Circ_0000442 is down-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It suppresses breast cancer progression by sponging miR-1229-3p, increasing ZBTB1 expression, inhibiting proliferation, migration, invasion and glycolysis, promoting apoptosis, and reducing xenograft tumor growth. |
| Confidence score: |
0.7373 |