| Expression pattern: |
UP |
| Associated gene: |
MCL1 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
circ-CEP128 promotes paclitaxel resistance, cell growth, migration, invasion and tumor growth, and inhibits apoptosis in cervical cancer; circ-CEP128 silencing enhances paclitaxel sensitivity. |
| Molecular mechanism: |
circ-CEP128 acts as a miR-432-5p sponge to positively regulate MCL1, thereby inhibiting paclitaxel sensitivity in cervical cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); chemoresistance (promotes); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ-CEP128 silencing might provide a new idea for improving the chemosensitivity of cervical cancer. |
| Description: |
circ-CEP128 is up-regulated in cervical cancer tissues and cells, especially in paclitaxel-resistant CC cells. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-432-5p to up-regulate MCL1, while circ-CEP128 knockdown enhances paclitaxel sensitivity and suppresses tumor growth. |
| Confidence score: |
0.7949 |