| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Hsa_circ_0071106 showed a tumor suppressor-like role in ESCC; its knockdown promoted ESCC cell migration and invasion, transient knockdown promoted proliferation, and reduced apoptosis. |
| Molecular mechanism: |
The study did not define a detailed molecular mechanism; it showed that downregulated hsa_circ_0071106 promotes ESCC progression by regulating cell migration and invasion. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; ROC Analysis |
| Clinical significance: |
Downregulated hsa_circ_0071106 was associated with histological differentiation grade and showed diagnostic value for ESCC and predictive value for histological differentiation. |
| Description: |
hsa_circ_0071106 is a human circRNA derived from ARHGAP10 that is downregulated in ESCC tissues and cell lines. Low expression is associated with poorer histological differentiation, and functional knockdown experiments indicate a tumor-suppressive role, mainly restraining ESCC cell migration and invasion, with transient effects on proliferation and apoptosis. The circRNA may serve as a diagnostic biomarker and a predictor of ESCC differentiation degree. |
| Confidence score: |
0.7969 |