| Expression pattern: |
UP |
| Associated gene: |
VEGFA, Ago2 |
| Associated microRNA: |
miR-567 |
| Biological function: |
promotes CRC cell proliferation and angiogenesis |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-567, relieving miR-567 inhibition of VEGFA, thereby increasing VEGFA and promoting proliferation and angiogenesis. |
| Biological pathway or process: |
proliferation (promotes); angiogenesis (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulation/high expression of Circ_0030998 is associated with lymph node metastasis, TNM stage, and poor prognosis; high Circ_0030998 levels had shorter survival and Circ_0030998 expression was an independent prognostic factor. |
| Description: |
Circ_0030998 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC proliferation, cell-cycle progression, and HUVEC angiogenesis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-567, thereby relieving miR-567-mediated repression of VEGFA. High Circ_0030998 expression is associated with shorter survival and serves as an independent prognostic factor in CRC. |
| Confidence score: |
0.7859 |