| Expression pattern: |
UP |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-125b-5p |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes cisplatin (DDP) resistance; promotes tumor growth in vivo |
| Molecular mechanism: |
circVAPA acts as a miRNA sponge for miR-125b-5p, thereby relieving miR-125b-5p-mediated repression of STAT3 and promoting chemoresistance and malignant phenotypes in gastric cancer cells. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
CircVAPA expression was elevated in clinical GC tissues compared with adjacent normal tissues, suggesting association with GC. |
| Description: |
CircVAPA is up-regulated in gastric cancer tissues and in cisplatin-resistant GC cells. It promotes proliferation, migration/invasion, tumor growth and cisplatin resistance while suppressing apoptosis, mainly by sponging miR-125b-5p and thereby increasing STAT3 signaling. |
| Confidence score: |
0.6287 |