| Expression pattern: |
UP |
| Associated gene: |
Pax-4, Pax-6, PPARalpha, PPAR-gamma |
| Associated microRNA: |
miR-4663 |
| Biological function: |
promotes proliferation and invasion; inhibits apoptosis (cell survival) |
| Molecular mechanism: |
circPVT1 may modulate miR-4663 and regulate Pax-4/Pax-6 and PPARalpha/PPAR-gamma protein levels |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circPVT1 is up-regulated in tissues and EC cell lines, which is associated with poor prognosis and may be a potential diagnostic biomarker for EC. |
| Description: |
circPVT1 is up-regulated in esophageal carcinoma tissues and EC cell lines. Functionally, circPVT1 promotes EC cell proliferation/survival and enhances invasion, while its knockdown increases apoptosis. Mechanistically, it is suggested to counteract miR-4663 effects and modulate Pax-4/Pax-6 and PPARalpha/PPAR-gamma protein levels, implying a circRNA-miRNA-protein regulatory axis. |
| Confidence score: |
0.6369 |