| Expression pattern: |
UP |
| Associated gene: |
EIF4A3, TCEAL6 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration and invasion and suppresses apoptosis in cervical cancer cells. |
| Molecular mechanism: |
Binds/recruits the RBP EIF4A3 to inhibit TCEAL6 expression by enhancing EIF4A3 binding to TCEAL6 mRNA and suppressing TCEAL6 translation. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
hsa_circ_0101119 is upregulated in cervical cancer and acts as an oncogenic circRNA by promoting proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it binds/recruits EIF4A3 to suppress TCEAL6 expression by enhancing EIF4A3 interaction with TCEAL6 mRNA and inhibiting TCEAL6 translation. |
| Confidence score: |
0.7295 |