circRNA basic information
circBase ID: hsa_circ_0072008
Name: hsa_circ_ZFR
Synonym: hsa_circRNA_103809
Host Gene: ZFR
Genomic location(hg19): chr5:32379220-32388780:-
Genomic location(hg38): chr5:32379114-32388674:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissues; adjacent normal tissues; xenograft tumour tissues
Cell lines:

SW1990; Hs 766 T; BXPC-3; PANC-1; HPDE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC7A11
Associated microRNA: miR-545-3p
Biological function: Circ_0072088 acts as an oncogenic circRNA in PDAC, promoting cell viability, proliferation, migration, invasion, tumour growth and glycolysis, while inhibiting apoptosis and oxygen consumption rate.
Molecular mechanism: Circ_0072088 functions through a ceRNA mechanism by targeting miR-545-3p and thereby regulating SLC7A11 expression in PDAC.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis
Clinical significance:

High circ_0072088 level was associated with high TNM stage and advanced TNM stage in PDAC patients.
Description:

Circ_0072088/hsa_circRNA_103809 is up-regulated in PDAC tumours and cell lines and its high expression is associated with advanced TNM stage. Functionally, circ_0072088 promotes PDAC cell viability, migration, invasion, tumour growth and glycolysis while suppressing apoptosis. Mechanistically, it acts through the circ_0072088/miR-545-3p/SLC7A11 ceRNA axis.
Confidence score:

0.7416
Other information
Title:

Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis.

Journal: Autoimmunity
Published: 2022
PubMed ID: 35166634
Study type:

combined biological and clinical study
Data availability: GSE69362; TCGA; The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -