| Expression pattern: |
DN |
| Associated gene: |
SMAD7 |
| Associated microRNA: |
miR-510-5p |
| Biological function: |
CircSIRT1 acts as a tumor suppressor in NSCLC cells by repressing proliferation, DNA replication, migration, invasion and glycolysis, while promoting apoptosis. |
| Molecular mechanism: |
CircSIRT1 functions as a miR-510-5p sponge to regulate SMAD7 and thereby restrains Wnt/beta-catenin signaling activation in NSCLC. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); glycolysis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
CircSIRT1 expression was associated with tumor-node-metastasis staging and tumor size in NSCLC patients, suggesting a probable therapeutic target for NSCLC treatment. |
| Description: |
CircSIRT1 is downregulated in NSCLC tissues and cell lines and is associated with TNM stage and tumor size. Functionally, circSIRT1 suppresses malignant NSCLC phenotypes including proliferation, invasion, migration and glycolysis while promoting apoptosis. Mechanistically, it acts through the miR-510-5p/SMAD7 axis to inhibit Wnt/beta-catenin signaling. |
| Confidence score: |
0.7591 |