| Expression pattern: |
UP |
| Associated gene: |
PLXNB2, AGO2 |
| Associated microRNA: |
miR-637 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0013958 sponges miR-637 to increase PLXNB2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0013958 could be used as a prognostic biomarker of OC patients (ROC AUC = 0.8806) |
| Description: |
circ_0013958 is up-regulated in ovarian cancer tissues and cell lines and acts as a tumor promoter. It mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-637, thereby increasing PLXNB2 expression to promote proliferation/migration/invasion and inhibit apoptosis; its silencing suppresses xenograft tumor growth. |
| Confidence score: |
0.7829 |